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KMID : 0363220110490040382
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Korean Journal of Dermatology
2011 Volume.49 No. 4 p.382 ~ p.384
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Erlotinib (Tarcevaⓡ) Induced Hair Abnormalities
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Choi Chang-Min
Lew Bark-Lynn
Sim Woo-Young
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Abstract
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Erlotinib is a low-molecular-weight quinazoline derivative that inhibits the activation of epidermal growth factor receptor (EGFR) tyrosine kinase through competitive binding of the adenosine triphosphate binding domain of the receptor. Patients undergoing anti-EGFR therapy frequently present with cutaneous reactions like a sterile follicular and pustular rash, xerosis, pruritus, paronychia, hair abnormalities and mucositis, which can cause serious discomfort and negatively affect the compliance with anti-EGFR therapy. We report here on an interesting case of hair abnormalities induced by erlotinib (Tarcevaⓡ) and this presented as eyelash lengthening and hair curling in a 62-year-old woman.
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KEYWORD
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Epidermal growth factor receptor inhibitor, Erlotinib, Hair abnormalities
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